C/EBP alpha Proteins

Protein Information

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues.  These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP.  One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells.  Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation.  From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

Synonyms

C EBP; C/EBP; C/EBP alpha; C/EBPa; C/ebpalpha; C/EBP-alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CBF-A; CCAAT enhancer binding protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; Cebp; CEBPA; DBPCEP; OTTHUMP00000220269